Charles L. Papp, MD is a board certified colorectal surgeon with with Colorectal Surgical & Gastroenterology Associates (CSGA).

Pregnancy‐associated plasma protein‐A (PAPP‐A) is a proteolytic enzyme that was discovered to increase local insulin‐like growth factor (IGF) availability for receptor activation through cleavage of …

Jun 2, 2023 · Pregnancy-associated plasma protein-A (PAPP-A) was first identified in the early 1970s as a placental protein of unknown function, present at high concentrations in the circulation of pregnant …

Jul 23, 2025 · Understand your PAPP-A results from first-trimester screening. Learn how this biomarker offers insight into fetal development and placental health.

PAPPA is a secreted protease whose main substrate is insulin-like growth factor binding proteins. Pappalysin-1 is also used in screening tests for Down syndrome. [2][3] PAPPA encodes a secreted …

Nov 29, 2023 · Pregnancy-associated plasma Protein A, commonly known as PAPPA, is a protein produced by the placenta during pregnancy. It is a crucial biomarker used to assess foetal well-being …

The PAPP-A test, also known as Pregnancy-Associated Plasma Protein-A test, is a blood test conducted during early pregnancy to assess the levels of a specific protein called PAPP-A. PAPP-A …

Aug 27, 2025 · The PAPP-A blood test in early pregnancy helps screen for potential growth issues and complications. Learn what it means, when it’s done, and why it matters.

Dec 22, 2022 · Originally discovered in the circulation of pregnant women as a protein secreted by placental trophoblasts, the metalloprotease pregnancy-associated plasma protein A (PAPP-A) is also …

Dec 1, 2024 · PAPP-A, a local regulator of insulin-like growth factor (IGF) signaling, is involved in multiple pathophysiological processes associated with CVD. PAPP-A was originally identified as one …