Over the past five years, the attorney general’s office, with Aaron Frey at the helm, has secured for Maine more than $260 million in settlements with major pharmaceutical companies accused of ...

Prescription pharmaceutical transdermal fentanyl is a valuable treatment for management of pain in opioid-tolerant patients, severe enough to require daily, around-the-clock, long-term opioid ...

The Canada Border Services Agency (CBSA) highlights results and accomplishments in the province of Ontario for the period between January 1 and October 31, 2025. Overview The CBSA plays a critical ...

Non-opioid analgesic shows efficacy in several animal pain models, including diabetic and chemotherapy-induced neuropathic ...

While the dangers of fentanyl have been dominating headlines for years, the death toll from another class of extremely potent synthetic opioids called “nitazenes” has been climbing steadily. For ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

Although recent data from the Centers for Disease Control and Prevention show signs of a reduction in annual opioid overdose deaths beginning in mid-2023, those rates remain above where they were when ...

Opioid medications will be required to have their labeling updated to highlight the safety risks of long-term use, the FDA announced on Thursday. The agency is requiring opioid manufacturers to add to ...

BACKGROUND AND OBJECTIVES: Methadone is a synthetic long-duration opioid with pharmacological properties qualitatively similar to morphine for its action on µ-opioid receptor. It is primarily used to ...

Jerry Abrams, a 64-year-old marketing strategist in Minneapolis, used to run marathons. But two decades of degenerative spine disease have left him unable to run — and he's grieving. For Abrams, ...

Drug overdose deaths in the U.S. plunged last year to their lowest level since 2019, according to the CDC. In 2024, nationwide overdose deaths fell by nearly 30,000 from the year before, a drop of ...