GPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors, are the largest receptor family in the human genome, with ≈800 members. GPCRs regulate nearly every aspect of human ...

While the COVID pandemic has thankfully been over for some time now, there is still a considerable number of people in the world (about 400 million) suffering from long COVID. Long COVID is a chronic ...

This valuable manuscript investigates the localisation of nutrient receptors in bloodstream stage trypanosomes, with implications for both nutrient uptake and immune evasion. Results after direct ...

Cholesterol, the most abundant sterol molecule in mammalian organisms, serves not only as a fundamental structural component of cell membranes but also as a critical regulator of cellular signaling ...

In a surprising discovery, scientists have found that the heart possesses 'sweet taste' receptors, similar to those on our tongues, and that stimulating these receptors with sweet substances can ...

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

A bitter taste receptor, TAS2R14, has been shown to respond to both extracellular and intracellular signals. Indeed, it can respond to both signals simultaneously. This finding is especially ...

This discovery gives us a new clue into how TAS2R14 works. It's fascinating because the receptor is not just sensing chemicals from outside the cell, like food or drugs, but also 'tasting' what's ...

High-resolution microscopic images of T cells that have been engineered with TGF-beta SNIPRs (shown in red) as they bind to TGF-beta (shown in green). The SNIPRs activate once the receptors fold into ...

Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3QZ, U.K. Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, ...