A pilot trial assessing apatinib in advanced head and neck squamous cell carcinoma that failed in previous standard chemotherapy or chemoradiotherapy. 5-fu continuous pump infusion via superficial ...
Background: The clinical evidence base for ototoxicity and nephrotoxicity outcomes with once-daily dosing (ODD) of gentamicin in children is suboptimal. Therapeutic drug monitoring (TDM) in once-daily ...
Cytotoxic effects of cisplatin occur primarily through apoptosis. Though several pro- and anti-apoptotic signaling molecules have been identified to play an important role in mediating the ototoxic, ...
The influence of dosage regimen on the nephrotoxicity, ototoxicity, and antibacterial efficacy of tobramycin was assessed in Fisher rats with Pseudomonas aeruginosa subcutaneous abscesses. A ...
Salicylate has recently been demonstrated to protect against the auditory and vestibular side effects of aminoglycoside antibiotics. Similarities in the toxic mechanisms suggest salicylate as a ...
Young children are at the greatest risk for acquiring hearing loss from cisplatin. 9 Infants and young children are at a critical stage of development in which hearing loss can negatively impact ...
Gentamicin is an aminoglycoside antibiotic, which is used to treat infections caused by aerobic gram-negative bacteria. Gentamicin in combination with penicillin has synergetic antibacterial effects ...
We found a low incidence of nephrotoxicity in a cohort of 79 children receiving 106 episodes of ODD of gentamicin for a median duration of 5 days. The incidence of ...
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