Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and disease progression. In gynecological malignancies-including ovarian, cervical, and ...
The field of cancer research is increasingly exploring the intricate intersections among epigenetics, cancer metabolism, and immunotherapy. These ...
In recent years, the complex ecosystem surrounding cancer cells, known as the tumor microenvironment (TME), has become a focal point of extensive scientific inquiry. The TME is composed of various ...
AARS, Alanyl-tRNA synthetase; AKT, protein kinase B; CC, cervical cancer; DCBLD1, discoidin, CUB, and LCCL domain-containing protein 1; EC, endometrial cancer; G6PD ...
A recent Science study explored how intranuclear metabolic enzymes establish the link between locus-specific epigenetic reprogramming of T cells and nutrient availability. Persistent antigen ...
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The race for cellular reprogramming: How one biotech built phase 3-level evidence while billion-dollar competitors remain in the lab
Jonas Salk quietly built the polio vaccine through rigorous, methodical work in Pittsburgh: treating patients, refinin ...
Metabolic reprogramming in fibrotic lung diseases involves key metabolites like lactate, succinate, and 2-hydroxyglutarate, driving inflammation and fibroblast activation. Lactate accumulation ...
EPFL scientists have identified a molecular pathway that protects cells from lipid oxidation and ferroptosis, a regulated ...
Global DNA-methylation is affected in G- cells. Global methylation level analysis in G− and G+ condition. (A) Bart chart representing the methylation level of individual sample (y-axis, 1 = 100%) in ...
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