Prostate adenocarcinoma is the most common malignancy diagnosed in males, and bone metastases remain a significant source of morbidity and mortality in this population. The ubiquitin-proteasome ...
A phase I trial of AEZS-108 (AN-152) in castration- and taxane-resistant prostate cancer. Background: The Src and IGF-1R axes are aberrantly activated in both PCa and the microenvironment of bone ...
Murine models of tumor development often require invasive procedures for tumor implantation, potentially causing pain or distress. However, analgesics are often withheld during implantation because of ...
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