Type I interferons can be induced by many kinds of viruses and nonviral pathogens and are important in innate immune responses for the control of infection. Host pattern-recognition receptors (PRRs) ...

Sexual transmission of HIV-1 is an inefficient process, with only one or few variants of the donor quasispecies establishing the new infection. A critical, and as yet unresolved, question is whether ...

Severe coronavirus disease 2019 (COVID-19) is associated with the development of acute respiratory distress syndrome (ARDS), characterized by exacerbated inflammation in the lungs and significantly ...

Saphnelo, a human monoclonal antibody, is a type 1 interferon (INF) receptor antagonist that inhibits a key protein in the immune system called the IFNAR receptor. This protein acts like a transmitter ...

Interferons are potent natural antivirals, rallying other parts of the immune system to defend against viruses. Some clinical trials have tested interferons as a treatment for COVID-19, but results ...

To test for interferon-like viral inhibitor, 0.2-ml. aliquots of a serum sample or dilutions thereof in LAE medium were inoculated into 2 tube cultures of human kidney and allowed to incubate for ...

Over the past 35 years, interferons have been explored in various formulations for the management of Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), such as essential ...

Your body makes interferons naturally. Three forms -- alpha, beta, and gamma -- control the activity of your immune system. But doctors also can use a man-made ...

Prolonged Survival of Dendritic Cell–Vaccinated Melanoma Patients Correlates With Tumor-Specific Delayed Type IV Hypersensitivity Response and Reduction of Tumor Growth Factor β-Expressing T Cells A ...

Multiple sclerosis is a chronic neurodegenerative disorder caused by the body’s autoimmune attack of the protective covering that surrounds nerves in the body. This substance is called myelin and ...